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One or more keywords matched the following properties of Concepcion, Axel
PropertyValue
keywords T Cells
keywords Cell Signaling
overview Our laboratory seeks to understand how membrane proteins and ion channels regulate the function of immune cells in health and disease. We use functional genomics and forward genetic screens to identify novel membrane proteins and ion channel regulators of immune cells. Our research team combines cross-disciplinary approaches including functional genomics, systems immunology, electrophysiology, and a wide range of cell and molecular biology techniques to understand the complex molecular networks regulated by ion channels in immune cells. Our goal is to advance our knowledge of how these plasma membrane proteins coordinate the immune responses to make fundamental and translational advances in immunotherapy.
One or more keywords matched the following items that are connected to Concepcion, Axel
Item TypeName
Concept Cell Differentiation
Concept Dendritic Cells
Concept Epithelial Cells
Concept Leukemia, B-Cell
Concept Cell Proliferation
Concept Calcium Signaling
Concept HEK293 Cells
Concept Lymphoma, B-Cell
Concept Programmed Cell Death 1 Receptor
Concept Cell Line, Tumor
Concept Th17 Cells
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Receptors, Antigen, T-Cell
Concept Signal Transduction
Academic Article Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells.
Academic Article The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling.
Academic Article Cavß1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.
Academic Article Dental enamel cells express functional SOCE channels.
Academic Article Eye on ion channels in immune cells.
Academic Article Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry.
Academic Article Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms.
Academic Article Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Academic Article CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.
Academic Article Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.
Academic Article STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.
Academic Article Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses.
Academic Article Role of AE2 for pHi regulation in biliary epithelial cells.
Academic Article Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease.
Academic Article Neurotransmitter signaling specifies sweat gland stem cell fate through SLN-mediated intracellular calcium regulation.
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  • Cell
  • signaling